This correlation may be useful for anticipating the need for repeat plasmapheresis. The Plasma Viscosity, alongside the ESR and C-Reactive Protein tests, gives a measure of the acute phase response i.e. Serum viscosity and electrophoresis are recommended before and after plasmapheresis in order to correlate viscosity and M-spike with patient symptoms. Hyperviscosity syndrome can also occur in multiple myeloma patients.īecause the ability of a monoclonal protein to cause hyperviscosity is affected by its concentration, molecular weight, and aggregation, sera with concentrations of monoclonal IgM greater than 4 g/dL, IgA greater than 5 g/dL, or IgG greater than 6 g/dL should be tested for hyperviscosity. The most common cause of serum hyperviscosity is the presence of large concentrations of IgM monoclonal proteins, and Waldenstrom macroglobulinemia accounts for 80% to 90% of hyperviscosity cases. Funduscopic examination reveals dilation of retinal veins and flame shaped retinal hemorrhages. Hyperviscosity may be manifested by nasal bleeding, blurred vision, headaches, dizziness, nystagmus, deafness, diplopia, ataxia, paresthesias, or congestive heart failure. ReferencesĬhandler WL and Schmer G, Evaluation of a new dynamic viscometer for measuring the viscosity of whole blood and plasma, Clin Chem (1986) 32:505.Viscosity is the property of fluids to resist flow. Hyperviscosity syndrome can also occur in multiple myeloma patients, and, rarely, in patients with rheumatoid factors and other aggregating proteins.
The most common cause of serum hyperviscosity is the presence of large concentrations of IgM monoclonal proteins, and Waldenstrom's macroglobulinemia accounts for 80% to 90% of symptomatic hyperviscosity cases. Although viscosities >1.6 are abnormal, hyperviscosity syndromes are rarely present unless the relative viscosity is >4.0 (approximately). Results are reported as a relative viscosity to water, where normal serum and plasma have a relative viscosity of up to 1.6. Serum, plasma or whole blood viscosity measurements can be useful in patients with hyperviscosity syndromes due to multiple myeloma or Waldenstrom's macroglobulinemia.
Viscosity is the property of fluids to resist flow. Lab Name Viscosity, Serum Lab Code SRVISG Epic Ordering
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